R&D Projects

Explore our R&D Projects page to discover our latest initiatives alongside contributions from byotic ⇀, our sister company. Dive into topics like bioreactors and filtration to stay informed about developments.

Photomicrograph of a breast tissue affected by lobular cancer, showing cancer cells grouped in the form of lobules. Home blog about the datroway

Datroway: Overview of therapies for metastatic breast cancer

Datroway therapies for metastatic breast cancer: targeted biotechnological solutions offering advanced treatment approaches

Green DNA structure used for the cover page on CASGEVY

CASGEVY: The First CRISPR-Cas9 Gene Therapy Approved in Europe

Learn about CASGEVY, the first gene therapy using CRISPR-Cas9 technology approved in Europe.

TECNIC's industrial filtration equipment, is the cover of the protein purification blog

Protein Purification: Effective Techniques for Industry

Discover key protein purification and separation techniques in bioprocessing, including chromatography and precipitation.

A white pill bottle tipped over with several white tablets spilling out, placed next to a syringe on a blue background, obesity treatment cover

Obesity treatment: 5 effective therapies to combat obesity

Discover the latest therapies for obesity treatment, including GLP-1 agonists, dual and triple drug combinations, gut hormone modulation and more.

Cover of the blog Single-use technology, there is a person holding a single-use bag.

Single-Use Technology and Its Environmental Impact

Learn how sustainable single-use technology impacts the environment while offering efficient, reliable solutions for modern bioprocessing needs.

3 Laboratory technicians working in a laboratory

Discover lab equipment for your research

Explore TECNIC’s advanced lab equipment: bioreactors, TFF systems, vessels and bioprocess bags designed for efficient and reliable research.

A person working in a laboratory, wearing a white coat, blue gloves and a hair cap. single-use bioreactors cover

Single-use bioreactors for personalised medicine

Discover TECNIC's single-use bioreactors for personalised medicine: safer, scalable, and designed for maximum efficiency in bioprocesses.

The image shows a TECNIC bioreactor made of stainless steel, next to a glass vessel designed to maintain a favourable environment, where micro-organisms or cells can be cultured.

What is Cell Culture? Complete guide on how it works

Explore cell culture fundamentals, key applications in biotech and medicine, and essential conditions for success in research and biopharma.

Image of the fat room during the TECNIC Innovation Tour

Innovation Tour showcasing biotech solutions

TECNIC's Innovation Tour in Girona showcased cutting-edge biotechnology solutions, fostering industry growth.

Mode	Element	Working pressure (bar[g])	Working pressure (psi[g])	T max (°C / °F)
Process	Vessel	0 / +2.5	0 / +36.3	+90 / 194
Process	Jacket	0 / +3.8	0 / +55.1	+90 / 194
Sterilisation	Vessel	0 / +2.5	0 / +36.3	+130 / 266
Sterilisation	Jacket	0 / +3.8	0 / +55.1	+150 / 302

Working volume	MU (Cell culture), reference	MB (Microbial), reference
10 L	0 to 300 rpm	0 to 1000 rpm
20 L	0 to 250 rpm	0 to 1000 rpm
30 L	0 to 200 rpm	0 to 1000 rpm
50 L	0 to 180 rpm	0 to 1000 rpm

Parameter	Typical value	Notes
Quantity	4 units (integrated)	In control tower; assignment defined by configuration
Speed	0-300 rpm	Variable control from eSCADA
Minimum flow	0-10 mL/min	Example with 0.8 mm ID tubing; depends on tubing and calibration
Maximum flow	Up to ~366 mL/min	Example with 4.8 mm ID tubing; actual flow depends on calibration
Operating modes	OFF / AUTO / MANUAL / PROFILE	AUTO typically associated to pH/DO/foam loops or recipe
Functions	PURGE, calibration, totaliser, PWM	PWM available for low flow setpoints below minimum operating level

Working volume (L)	VVM min	VVM max	Air (L/min)	O2 (10%) (L/min)	CO2 (20%) (L/min)	N2 (10%) (L/min)
10	0.5	1.5	5-15	0.5-1.5	1-3	0.5-1.5
20	0.5	1.5	10-30	1-3	2-6	1-3
30	0.5	1.5	15-45	1.5-4.5	3-9	1.5-4.5
50	0.5	1.5	25-75	2.5-7.5	5-15	2.5-7.5

Variable / function	Typical technology / interface	Status (STD/OPT)
Temperature (process/jacket)	Pt100 class A RTD	STD
Pressure (vessel/lines)	Pressure transmitter (4-20 mA / digital)	STD
Level (working volume)	Adjustable probe	STD
pH	Digital pH sensor (ARC or equivalent)	STD
DO (pO2)	Digital optical DO sensor (ARC or equivalent)	STD
Foam	Conductive/capacitive foam sensor	STD
Weight / mass balance	Load cell (integrated in skid)	STD
pCO2	Digital pCO2 sensor (ARC or equivalent)	OPT
Biomass (permittivity)	In-line or in-vessel sensor	OPT
VCD / TCD	In-situ cell density sensors	OPT (MU)
Off-gas (O2/CO2)	Gas analyser for OUR/CER	OPT
ORP / Redox	Digital ORP	OPT
Glucose / Lactate	PAT sensor	OPT

Utility	Typical service / configuration	Pressure	Flow / power	Notes
Electrical	EU base: 400 VAC / 50 Hz (3~)	N/A	AutoSIP: 12 kW; External SIP: 5 kW	NA option: 480 VAC / 60 Hz; cabinet/wiring per NEC/NFPA 70; UL/CSA as required
Process gases	Air / O2 / CO2 / N2	Up to 2.5 bar(g) (36.3 psi)	According to setpoint	Typical OD10 pneumatic connections; final list depends on package
Instrument air	Pneumatic valves	Up to 6 bar(g) (87.0 psi)	N/A	Dry/filtered air recommended
Cooling water	Jacket cooling water	2 bar(g) (29.0 psi)	25 L/min (6.6 gpm)	6-10 °C (43-50 °F) typical
Cooling water	Condenser cooling water	2 bar(g) (29.0 psi)	1 L/min (0.26 gpm)	6-10 °C (43-50 °F) typical
Steam (External SIP)	Industrial steam	2-3 bar(g) (29.0-43.5 psi)	30 kg/h (66 lb/h)	For SIP sequences
Steam (External SIP)	Clean steam	1.5 bar(g) (21.8 psi)	8 kg/h (18 lb/h)	Depending on plant strategy

Scope	EU (typical references)	North America (typical references)
Pressure equipment	PED 2014/68/EU	ASME BPVC Section VIII (where applicable)
Hygienic design	Hygienic design good practices	ASME BPE (reference for bioprocessing)
Machine safety	Machinery: 2006/42/EC (until 13/01/2027) / (EU) 2023/1230	OSHA expectations; NFPA 79 (industrial machinery) - project dependent
Electrical / EMC	LVD 2014/35/EU; EMC 2014/30/EU	NEC/NFPA 70; UL/CSA components and marking as required
Materials contact	EC 1935/2004 + EC 2023/2006 (GMP for materials) where applicable	FDA 21 CFR (e.g., 177.2600 for elastomers) - materials compliance
Software / CSV	EU GMP Annex 11 (if applicable)	21 CFR Part 11 (if applicable)

Tank model	Nominal volume	Minimum volume to start agitation*
Tank 50 L	50 L	15 L
Tank 100 L	100 L	20 L
Tank 200 L	200 L	30 L
Tank 500 L	500 L	55 L

Element	Operating pressure	Maximum pressure (safety)	Maximum working temperature
ePlus Mixer (control tower)	ATM	0.5 bar(g)	90 °C
Tank	ATM	0.5 bar(g)	45 °C
Jacket (if applicable)	N/A	1.5 bar	Depends on utilities / scope

R&D Projects

Cellular configuration

Cellular configuration

Cellular configuration

Microbial configuration

Cellular configuration

Technical specifications

Materials and finishes

Design conditions

Pressure control and safeguards

Agitation

Integrated peristaltic pumps (additions)

Gas flow control (microbial reference capacity)

Instrumentation and sensors

Automation, software and connectivity

Utilities

Compliance and deliverables

Ordering and configuration

Cellular configuration

Technical specifications

Cellular configuration

Technical specifications

Models and working volumes

Design conditions and operating limits

Materials and finishes

Agitation system

Weighing and volume control

Pumps and fluid handling

Thermal management (optional jacket)

Instrumentation and sensors

Automation, software and data

Utilities and facility interfaces

Documentation and deliverables

Ordering and configuration

Cellular configuration

Scale

Bioreactors engineered for smooth scale-up

From S to XL, with a clear scale path